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| Product Name | HCV-N24 protein |
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| Description | HCV-N24 protein.The protein contains the HCV core nucleocapsid immunodominant regions. The protein is fused withb-galactosidase (114 kDa) at the N-terminus.Hepatitis C Virus core proteins are purified by proprietarychromatographic techniques.The hepatitis C virus (HCV) core protein represents thefirst 191 amino acids of the viral precursor polyproteinand is cotranslationally inserted into the membrane of theendoplasmic reticulum (ER)Hepatitis C virus (HCV) core is a viral structural protein;it also participates in some cellular processes, includingtranscriptional regulation. However, the mechanisms ofcore-mediated transcriptional regulation remain poorlyunderstood. Hepatitis C virus (HCV) core protein isthought to contribute to HCV pathogenesis through itsinteraction with various signal transduction pathwaysIn addition, HCV core antigen is a recently developedmarker of hepatitis C infection. It is remarkably efficientat establishing persistent infection, suggesting that ithas evolved one or more strategies aimed at evadingthe host immune response. T cell responses, includinginterferon-gamma production, are severely suppressedin chronic HCV patients. The HCV core protein hasbeen previously shown to circulate in the bloodstream ofHCV-infected patients and inhibit host immunity throughan interaction with gC1qR. Purity >95% by SDS-PAGE |
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| Size | 1 mg, 100 ug |
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| Concentration | n/a |
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| Applications | ELISA, WB |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | orb97900 |
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| Order / More Info | HCV-N24 protein from BIORBYT LTD. |
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| Product Specific References | n/a |
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