| 产品详情 |
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| Product Name | Fructose 1,6-bisphosphatase-1 Inhibitor |
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| Description | Purity >98%. Fructose-1,6-bisphosphatase-1 (FBPase-1) is an enzyme that catalyzes the conversion of fructose-1,6-bisphosphate to fructose-6-phosphate, which is one of the rate-limiting steps in gluconeogenesis. Excess hepatic FBPase-1 activity contributes to hyperglycemia in patients. Thus, the development of specific FBPase-1 inhibitors is of great clinical interest for the treatment of patients with type 2 diabetes. FBPase-1 inhibitor is a cell-permeable benzoxazolo-sulfonamide compound that blocks human FBPase-1 enzymatic activity with an IC50 value of 3.4 µM (Ki = 1.1 µM) by competing at the AMP allosteric binding site. It has been shown to block glucose production in rat hepatoma cells that are starved of nutrients with an IC50 value of 6.6 µM. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2,5-dichloro-N-(5-chloro-2-benzoxazolyl)-benzenesulfonamide, F1,6BPase-1 Inhibitor, FBP1 Inhibitor, FBPase-1 Inhibitor |
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| Gene, Accession, CAS # | CAS: 883973-99-7 |
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| Catalog # | LS-H7849 |
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| Order / More Info | Fructose 1,6-bisphosphatase-1 Inhibitor from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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