| 产品详情 |
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| Antigenic Specificity | E-cadherin |
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| Clone | NCH-38 |
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| Host Species | Mouse |
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| Reactive Species | human, mouse |
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| Isotype | IgG1, kappa |
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| Format | purified |
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| Size | 500 µL |
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| Concentration | n/a |
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| Applications | Immunohistochemistry (Paraffin): 1:20, Western Blot: 1:250 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | E-cadherin Monoclonal Antibody (NCH-38). E-Cadherin (epithelial cadherin) is a classical cadherin from the cadherin (alcium dependent adhesion protein) superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants ar |
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| Immunogen | n/a |
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| Other Names | Arc-1, CD324, CDHE, ECAD, LCAM, UVO, CAM 120/80, E-Cadherin, cadherin 1, E-cadherin epithelial, cadherin-1, calcium-dependent adhesion protein, epithelial, cell-CAM 120/80, epithelial cadherin, uvomorulin, cadherin-E |
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| Gene, Accession # | Entrez: 12550, 999; Uniprot: P09803, P12830 |
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| Catalog # | MA5-12547 |
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| Price | |
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| Order / More Info | E-cadherin Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | PubMed: 15656885, 17877616, 18261623, 18758639, 19107681, 21683373, 23030630 |
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