| 产品详情 |
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| Product Name | Skepinone-L |
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| Description | Purity >98%. Skepinone-L is an ATP-competitive inhibitor of p38 MAPK isoform p38Alpha (IC50 s = 5 nM) and p38Beta (97% inhibition at 1 µM). It has little effect on a range of other kinases, including p38Gamma and p38Delta. Skepinone-L dose-dependently blocks the phosphorylation of heat shock protein 27 (HSP27), a p38 MAPK substrate, in response to stimulation with anisomycin in HeLa cells (IC50 = 25 nM) or TNF-Alpha in THP-1 cells. At 1 µM, it prevents phosphorylation of cytosolic phospholipase A2 in platelets in response to collagen-related peptide or thrombin , blunting platelet secretion and aggregation. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2-[(2,4-difluorophenyl)amino]-7-[(2R )-2,3-dihydroxypropoxy]-10,11-dihydro-5H -dibenzo[a ,d ]cyclohepten-5-one |
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| Gene, Accession, CAS # | CAS: 1221485-83-1 |
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| Catalog # | LS-H9936 |
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| Price | |
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| Order / More Info | Skepinone-L from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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