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| Product Name | SR 0987 |
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| Description | Purity >98%. SR 0987 is an agonist of the T cell-specific isoform of RORGamma (RORGammat, retinoic acid receptor-related orphan receptor-Gammat), inducing reporter gene expression with an EC50 value of ~800 nM. Stimulation of mouse EL4 T lymphocytes with SR 0987, following activation with PMA and ionomycin , increases expression of the RORGammat target IL-17, while expression of the programmed cell death protein PD-1 is decreased and granzyme B is unchanged. Decreased cell surface PD-1 protein, assessed by flow cytometry, is observed in a variety of T cells treated with SR 0987. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2-chloro-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-benzamide |
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| Gene, Accession, CAS # | CAS: 303126-97-8 |
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| Catalog # | LS-H10003 |
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| Order / More Info | SR 0987 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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