| 产品详情 |
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| Antigenic Specificity | Osteopontin |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | canine, human, porcine |
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| Isotype | n/a |
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| Format | purified |
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| Size | 500 µL |
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| Concentration | n/a |
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| Applications | Immunohistochemistry (Paraffin): 1:50-100, Western Blot: 2-4 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Osteopontin Polyclonal Antibody. Osteopontin is an arginine-glycine-aspartic acid (RGD)-containing glycoprotein that interacts with integrins and CD44 as major receptors. It is a multifunctional protein involved in bone mineralization, cell adhesion, cell migration, chronic inflammatory disease and transformation. Proteolytic cleavage by thrombin and matrix metalloproteinases close to the integrin-binding Arg-Gly-Asp sequence modulates the function of OPN and its integrin binding properties. Thrombin-cleaved fragments of Osteopontin are overexpressed in malignant glial tumors and provide a molecular niche with survival advantage and provide a novel substrate for plasmin and cathepsin D. |
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| Immunogen | n/a |
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| Other Names | SPP-1, SPP1/CALPHA1 fusion, bone sialoprotein 1, bone sialoprotein I, early T-lymphocyte activation 1, nephropontin, osteopontin, osteopontin/immunoglobulin alpha 1 heavy chain constant region fusion protein, secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1), secreted phosphoprotein-1 (osteopontin, bone sialoprotein), urinary stone protein, uropontin |
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| Gene, Accession # | Entrez: 397087, 478471, 6696; Uniprot: P10451, P14287 |
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| Catalog # | PA5-16821 |
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| Price | |
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| Order / More Info | Osteopontin Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | PubMed: 20070748, 20443798, 22274591, 22701304, 23851606, 23994637 |
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