| 产品详情 |
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| Product Name | Flavokawain B |
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| Description | Purity >98%. Flavokawain B is a natural chalcone first isolated from extracts of kava roots. It induces apoptosis in androgen receptor-negative, hormone-refractory prostate cancer cell lines (IC50 s = 32, 48, 6.2, and 3.9 µM for LAPC4, LNCaP, PC-3, and DU145 cells, respectively, treated for 48 hours), with increased expression of the proapoptotic protein Bim. Flavokawain B increases Bim expression and inhibits growth of DU145 xenografts in mice. It also increases Bim expression, promotes apoptosis, and induces cell cycle arrest in uterine leiomyosarcoma cells. However, flavokawain B is hepatotoxic, triggering oxidative stress, inhibiting NF-?B signaling, and activating MAPK pathways, culminating in HepG2 and L-02 cell death (LD50 s = 15 and 32 µM, respectively). |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | (2E)-1-(2-hydroxy-4,6-dimethoxyphenyl)-3-phenyl-2-propen-1-one |
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| Gene, Accession, CAS # | CAS: 1775-97-9 |
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| Catalog # | LS-H7800 |
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| Order / More Info | Flavokawain B from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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