| 产品详情 |
| Edit |   |
|---|
| Product Name | Flavopiridol |
|---|
| Description | Purity >95%. The positive transcription elongation factor (P-TEFb) is a protein kinase composed of cyclin-dependent kinase (Cdk) 9 and a cyclin subunit. P-TEFb controls the elongation phase of transcription by RNA polymerase II. It is also a cellular co-factor required for activation of transcription of the human immunodeficiency virus (HIV)-1 genome by the viral transactivator Tat. Flavopiridol is a potent, orally available inhibitor of CDKs. It most effectively blocks the Cdk9 activity of P-TEFb (IC50 = 8 nM), which in turn can prevent transcription or HIV-1 replication. Flavopiridol inhibits all other CDK isoforms (IC50 = 100-300 nM). It less effectively inhibits epidermal growth factor receptor and protein kinase A (IC50 = 21 and 122 µM, respectively). It has potential applications in cancer therapy, particularly in combination with other modulators. Flavopiridol also suppresses synovial hyperplasia and joint destruction in collagen-induced arthritis in mice. |
|---|
| Size | n/a |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-4H-1-benzopyran-4-one, Alvocidib, HMR 1275, HL 275, L-868,275 |
|---|
| Gene, Accession, CAS # | CAS: 131740-09-5 |
|---|
| Catalog # | LS-H7802 |
|---|
| Price | |
|---|
| Order / More Info | Flavopiridol from LIFESPAN BIOSCIENCES INC. |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|