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| Product Name | RWJ 67657 |
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| Description | Purity >95%. RWJ 67657 is an orally active inhibitor of the MAP kinases p38Alpha and p38Beta (IC50 s = 1 and 11 µM, respectively, in vitro ) that is inactive against p38Gamma and p38Delta, as well as several other kinases. It blocks the release of TNF-Alpha and IL-1Beta from peripheral blood mononuclear cells stimulated with LPS (IC50 s = 3 and 11 nM, respectively) and inhibits TNF-Alpha production in LPS-treated mice and rats. RWJ 67657 potently blocks the proliferation of CD4+ peripheral blood T cells induced by CD28 stimulation alone (IC50 = 0.5-4 nM). It is commonly used to study the roles of p38Alpha and p38Beta in cellular and whole animal systems. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 4-[4-(4-fluorophenyl)-1-(3-phenylpropyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]-3-butyn-1-ol, JNJ-3026582 |
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| Gene, Accession, CAS # | CAS: 215303-72-3 |
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| Catalog # | LS-H9791 |
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| Price | |
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| Order / More Info | RWJ 67657 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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