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| Product Name | Human TNFRSF1A / TNFR1 Protein (Recombinant) |
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| Description | Purity >98% by SDS-PAGE gel and HPLC analyses., MW: 18.3 kDa. TNFRI belongs to the TNFR superfamily of transmembrane proteins, and is expressed in most cell types. Binding of either TNF-a or TNF-β to TNFRI initiates a signal transduction pathway that results in the activation of the transduction factor NF-?B, whose target genes are involved in the regulation of inflammatory responses, and, in certain cells induce apoptosis. Soluble TNF Receptor I (sTNFRI) is capable of inhibiting TNF-a and TNF-β activities by acting as a decoy receptor that serves as a sink for the TNF ligands. The human TNFRI gene encodes for a 455 amino acid type I transmembrane protein, which contains a 21 amino acid signal sequence, a 190 amino acid extracellular domain, a 23 amino acid transmembrane domain, and a 221 amino acid cytoplasmic domain. Recombinant Human sTNF Receptor Type I is an 18.3 kDa protein (162 amino acid residues) comprising the cysteine-rich, ligand-binding portion of the extracellular domain of the TNFRI protein. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | TNFRSF1A, CD120a, CD120a antigen, MS5, p60, TBP1, TNF-R55, TNFAR, TNFR1, p55-R, TNF-R, TNF-R-I, TNF-R1, TNF-RI, Tnfr, TNFR-I, TNFR1-d2, TNFR60, FPF, p55, Tbpi, TNFR55 |
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| Gene, Accession, CAS # | TNFRSF1A, Gene ID: 7132 |
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| Catalog # | LS-G133847 |
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| Order / More Info | Human TNFRSF1A / TNFR1 Protein (Recombinant) from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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