| 产品详情 |
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| Product Name | FSC-231 |
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| Description | Purity >98% by NMR, TLC. FSC-231 is the first small-molecule inhibitor of the PDZ domain in protein interacting with C kinase 1 (PICK1). Binds to PICK1 PDZ domain with affinity similar to that of the endogenous peptide ligands (Ki~10.1 uM). Does not bind to PDZ domains of postsynaptic density protein 95 (PSD-95) nor glutamate receptor interacting protein 1 (GRIP1). Pretreatment of cultured hippocampal neurons inhibits coimmunoprecipitation of the AMPA receptor GluR2 subunit with PICK1. FSC231 accelerated recycling of fluorophore-tagged GluR2 in hippocampal neurons after internalization in response to NMDA receptor activation. Blocks the expression of both long-term depression and long-term potentiation. Attenuates cocaine seeking in a rodent model. Blocks PICK1-induced anti-inflammatory effect in acute liver injury. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | (E)-Ethyl-2-cyano-3-(3,4-dichlorophenyl)acryloylcarbamate |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | LS-H14504 |
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| Order / More Info | FSC-231 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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