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| Product Name | 3-(4-Pyridyl)indole |
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| Description | Purity >98%. Two Rho-associated kinases (ROCK), ROCK-I and ROCK-II, act downstream of the G protein Rho to regulate cytoskeletal stability. The ROCKs play important roles in diverse cellular functions including cell adhesion and proliferation, smooth muscle contraction, and stem cell renewal. 3-(4-Pyridyl)indole is a ROCK-I inhibitor (IC50 = 25 µM) that promotes cell spreading, inhibits membrane blebbing, and induces dissolution of actin stress fibers in a wound healing assay. It also inhibits ROCK-II and PRK2, another Rho-dependent kinase, with similar potency, while inhibiting MSK-1 and PKA with relatively weaker potency. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 3-(4-pyridinyl)-1H-indole, Rho Kinase Inhibitor III, ROCK Inhibitor III, Rockout |
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| Gene, Accession, CAS # | CAS: 7272-84-6 |
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| Catalog # | LS-H6026 |
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| Order / More Info | 3-(4-Pyridyl)indole from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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