| 产品详情 |
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| Product Name | (S)-PFI-2 (hydrochloride) |
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| Description | Purity >95%. SET domain-containing protein 7/9 (SET7/9) is a histone methyltransferase that monomethylates lysine 4 of histone H3, which generates a specific tag for epigenetic transcriptional activation. It plays a role in the transcriptional activation of tumor suppressor p53 in response to DNA damage, as well as the transcription factor TAF10. (R)-PFI-2 is a potent, cell-permeable inhibitor of SET7/9 (IC50 = 2 nM) that demonstrates greater than 1,000-fold selectivity over a panel of 18 other methyltransferases. (S)-PFI-2, the inactive enantiomer, is 500-fold less potent (IC50 = 1 µM) and may serve as a negative control. See the Structural Genomics Consortium (SGC) website for more information. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 8-fluoro-1,2,3,4-tetrahydro-N-[(1S)-2-oxo-2-(1-pyrrolidinyl)-1-[[3-(trifluoromethyl)phenyl]methyl]ethyl]-6-isoquinolinesulfonamide, monohydrochloride, (+)-PFI-2 |
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| Gene, Accession, CAS # | CAS: 1627607-88-8 |
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| Catalog # | LS-H5691 |
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| Price | |
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| Order / More Info | (S)-PFI-2 (hydrochloride) from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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