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| Product Name | Recombinant Mouse Negative regulator of reactive oxygen species (Nrros), partial |
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| Description | Purity > 85% as determined by SDS-PAGE. MW: 73.2kDa. Partial: 29-651aa. N-terminal 6xHis-tagged. Mus musculus (Mouse). Key regulator of transforming growth factor beta-1 specifically required for microglia function in the nervous system. Required for activation of latent TGF-beta-1 in macrophages and microglia: associates specifically via disulfide bonds with the Latency-associated peptide, which is the regulatory chain of TGFB1, and regulates integrin-dependent activation of TGF-beta-1. TGF-beta-1 activation mediated by LRRC33/NRROS is highly localized: there is little spreading of TGF-beta-1 activated from one microglial cell to neighboring microglia, suggesting the existence of localized and selective activation of TGF-beta-1 by LRRC33/NRROS. Indirectly plays a role in Toll-like receptor signaling: ability to inhibit TLR-mediated NF-kappa-B activation and cytokine production is probably a consequence of its role in TGF-beta-1 signaling. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Leucine-rich repeat-containing protein 33 (Negative regulator of reactive oxygen species) (Lrrc33) |
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| Gene, Accession, CAS # | Nrros, UniProt: Q8BMT4 |
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| Catalog # | RPC26277 |
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| Order / More Info | Recombinant Mouse Negative regulator of reactive oxygen species (Nrros), partial from BIOMATIK |
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| Product Specific References | n/a |
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