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| Product Name | Neuromedin U-25 (human) |
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| Description | Neuromedin U (NMU) is a neuropeptide first demonstrated to drive smooth muscle contraction. Translated as a 174 amino acid propeptide, NMU is cleaved to different lengths in different animals. It has diverse receptor-mediated roles in vivo, as it regulates feeding, vasoconstriction, nociception, and bone remodeling and contributes to obesity, cancer and septic shock. NMU-25 is the active form of NMU in humans. It binds with high affinity to receptors on human left ventricle and coronary artery (KD s = 0.26 and 0.11 nM, respectively), eliciting endothelium-independent vasoconstriction. NMU-25 also suppresses glucose-stimulated insulin secretion in human islets, and this effect is lost in NMU R165W mutants, resulting in early-onset obesity. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | L-phenylalanyl-L-arginyl-L-valyl-L-a-aspartyl-L-a-glutamyl-L-a-glutamyl-L-phenylalanyl-L-glutaminyl-L-seryl-L-prolyl-L-phenylalanyl-L-alanyl-L-seryl-L-glutaminyl-L-seryl-L-arginylglycyl-L-tyrosyl-L-phenylalanyl-L-leucyl-L-phenylalanyl-L-arginyl-L-prolyl-L, NMU-25 |
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| Gene, Accession, CAS # | CAS: 312306-89-1 |
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| Catalog # | LS-H8973 |
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| Order / More Info | Neuromedin U-25 (human) from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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