| 产品详情 |
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| Product Name | Ryuvidine |
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| Description | Purity >95%. SET domain-containing protein 8 (SETD8) is a methyltransferase that selectively monomethylates histone H4 at lysine residue 20 (H4K20), an event proven to have an important role in chromatin structure and transcriptional activation. It is also a regulator of p53, mono-methylating lysine 382 of the tumor suppressor. Ryuvidine is an inhibitor of SETD8 (IC50 = 0.5 µM) that suppresses monomethylation of H4K20 in vitro . It less potently inhibits cyclin-dependent kinase 4 (Cdk4; IC50 = 6 µM for Cdk4/cyclin D1). Over several hours of treatment, ryuvidine suppresses the expression of cell division cycle 7-related kinase (Cdc7), resulting in an ATM-dependent checkpoint response and arrest of cell cycling in S phase. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2-methyl-5-[(4-methylphenyl)amino]-4,7-benzothiazoledione, Cdk4 Inhibitor III, Cyclic-dependent Kinase 4 Inhibitor III, SPS812 |
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| Gene, Accession, CAS # | CAS: 265312-55-8 |
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| Catalog # | LS-H9793 |
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| Price | |
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| Order / More Info | Ryuvidine from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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