| 产品详情 |
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| Product Name | BI-6015 |
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| Description | Purity >98% by NMR, TLC. BI-6015 is a hepatocyte nuclear factor 4a (HNF4a) antagonist. HNF4a is a central regulator of gene expression in cell types that play a central role in metabolic homeostasis. BI-6015 binds to HNF4a with high affinity and modulates the expression of known target genes. It was shown to be selectively cytotoxic to cancer cell lines in vitro and in vivo however in vivo potency was limited by suboptimal pharmacokinetics. BI-6015 represents the first small molecule tool for pharmacologic modulation of HNF4a activity. Cell permeable. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2-Methyl-1-[(2-methyl-5-nitrophenyl)sulfonyl]-1H-benzimidazole |
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| Gene, Accession, CAS # | CAS: 93987-29-2 |
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| Catalog # | LS-H14616 |
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| Order / More Info | BI-6015 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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