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| Product Name | Recombinant Human ADP-ribosylation factor 1 (ARF1) |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 50.6kDa. Full Length of Mature Protein: 2-181aa. N-terminal 10xHis-GST-tagged and C-terminal Myc-tagged. Homo sapiens (Human). GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles. The GTP-bound form interacts with PICK1 to limit PICK1-mediated inhibition of Arp2/3 complex activity; the function is linked to AMPA receptor (AMPAR) trafficking, regulation of synaptic plasicity of excitatory synapses and spine shrinkage during long-term depression (LTD). |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | n/a |
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| Gene, Accession, CAS # | ARF1, UniProt: P84077 |
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| Catalog # | RPC20925 |
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| Order / More Info | Recombinant Human ADP-ribosylation factor 1 (ARF1) from BIOMATIK |
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| Product Specific References | n/a |
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