| 产品详情 |
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| Antigenic Specificity | CD279 (PD-1) |
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| Clone | J116 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1, kappa |
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| Format | unconjugated, functional grade |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Flow Cytometry: 1 µg/test, Functional Assay: Assay-Dependent |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | CD279 (PD-1) Monoclonal Antibody (J116), Functional Grade, eBioscience™. Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of danger signals such as LPS or other molecules associated with bacteria or other pathogens. Evidence for this is seen in PD1-null mice |
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| Immunogen | n/a |
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| Other Names | PD1 |
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| Gene, Accession # | Entrez: 5133; Uniprot: Q15116 |
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| Catalog # | 16-9989-82 |
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| Price | |
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| Order / More Info | CD279 (PD-1) Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | PubMed: 12091876, 15374887, 16282703, 18294387, 18550794, 18566376, 24894091, 25073001, 25979485, 27446371, 27467927, 27533458 |
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