| 产品详情 |
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| Product Name | Syk Inhibitor |
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| Description | Purity >95%. Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that upon phosphorylation binds to immunoreceptor tyrosine-based activation motifs (ITAMs) of FcRGamma chains and mediates downstream signaling related to platelet function and inflammation. Syk inhibitor is an oxindole compound that potently blocks Syk activity with an IC50 value of 5 nM and inhibits FceRI-mediated rat RBL-2H3 basophil cell degranulation (EC50 = 1.4 µM). At 2 µM, this compound completely abolishes convulxin-induced platelet aggregation and shape change. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2,3-dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2-oxo-1H-indole-5-sulfonamide, OXSI 2, Spleen Tyrosine Kinase |
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| Gene, Accession, CAS # | CAS: 622387-85-3 |
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| Catalog # | LS-H10077 |
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| Order / More Info | Syk Inhibitor from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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