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| Product Name | Hedgehog Antagonist VIII |
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| Description | Purity >98%. Hedgehog (Hh) proteins, important regulators of development, bind the cell-surface protein Patched, allowing activation of Smoothened. In vertebrates, this ultimately leads to the activation of the zinc-finger transcription factors of the Gli family. Overactivation of this pathway contributes to certain cancers, including glioblastoma, for which the Gli proteins are named. Hh antagonist VIII is a cell-permeable quinazolinyl-urea compound that has been shown to inhibit Gli transcription activity with an IC50 value of 70 nM. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-[4-chloro-3-(trifluoromethyl)phenyl]-N'-[[3-(4-fluorophenyl)-3,4-dihydro-4-oxo-2-quinazolinyl]methyl]-urea, Hh Antagonist VIII |
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| Gene, Accession, CAS # | CAS: 330796-24-2 |
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| Catalog # | LS-H8083 |
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| Order / More Info | Hedgehog Antagonist VIII from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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