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Product Name | HMB-Val-Ser-Leu-VE |
Description | Purity >98%. The 20S proteasome is a 700 kDa, multi-subunit cylinder-shaped protein that functions as the central protease within the ubiquitin-proteasome pathway utilized by cells for the regulated degradation of proteins. HMB-val-ser-leu-VE is a tripeptide bearing a C-terminal vinyl ester which acts as a potent, selective inhibitor of the trypsin-like activity of the 20S proteasome. It inhibits the tryptic-like, chymotryptic-like, and post acidic activities of the purified 20S proteasome with IC50 values of 0.33 µM, >10 µM, and >10 µM, respectively. HMB-val-ser-leu-VE is cell permeable and stable (t1/2 ~6 hours) in in vitro assays. |
Size | n/a |
Concentration | n/a |
Applications | n/a |
Other Names | N-(3-hydroxy-2-methylbenzoyl)-L-valyl-N-[(1S,2E)-4-ethoxy-1-(2-methylpropyl)-4-oxo-2-butenyl]-L-serinamide |
Gene, Accession, CAS # | CAS: 862891-04-1 |
Catalog # | LS-H8113 |
Price | |
Order / More Info | HMB-Val-Ser-Leu-VE from LIFESPAN BIOSCIENCES INC. |
Product Specific References | n/a |
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