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| Product Name | 22(R)-hydroxy Cholesterol |
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| Description | Purity >98%. The liver X receptors (LXRAlpha and LXRBeta) are nuclear hormone receptors whose native ligands are oxysterols. LXRs regulate the oxysterol-induced expression of cholesterol 7Alpha-hydroxylase, the rate limiting enzyme of classic bile acid synthesis. 22(R)-hydroxy Cholesterol is an endogenous agonist for LXRs that activates LXRAlpha with an EC50 value of 325 nM. 22(R)-hydroxy Cholesterol, acting through LXR heterodimerized with the retinoid X receptor, induces the expression of the ABCA1 reverse cholesterol transporter. This activity increases the efflux of cholesterol from enterocytes and thus inhibits the overall absorption of cholesterol. 22(R)-hydroxy Cholesterol can be used as a substrate to monitor cholesterol transport or as an endogenous positive control for testing LXR agonists which have potential as therapeutic agents for the treatment of atherosclerosis. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | cholest-5-ene-3Beta,22R-diol, Narthesterol |
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| Gene, Accession, CAS # | CAS: 17954-98-2 |
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| Catalog # | LS-H5950 |
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| Price | |
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| Order / More Info | 22(R)-hydroxy Cholesterol from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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