| 产品详情 |
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| Product Name | CPI-455 |
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| Description | Purity >98% by HPLC. CPI-455 is a potent and selective KDM5A inhibitor (IC50 ~10 nM). It inhibits KDM5A, KDM5B and KDM5C to similar extents but shows substantially weaker potency toward KDM4C and KDM7B (~200- and 770-fold, respectively) and no detectable inhibition of KDM2B, KDM3B or KDM6A. It specifically alters H3K4 methylation in cells and binds at the demethylase active site. CPI-455-mediated KDM5 inhibition leads to a dose-dependent increase in global H3K4me3 in HeLa cells, and the removal of CPI-455 resulted in a rapid reversal of H3K4me3 increases in HeLa cells. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 6-Isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile |
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| Gene, Accession, CAS # | CAS: 1628208-23-0 |
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| Catalog # | LS-H4287 |
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| Price | |
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| Order / More Info | CPI-455 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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