| 产品详情 |
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| Product Name | SL 0101-1 |
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| Description | Purity >98%. The p90 ribosomal S6 kinases (RSK) 1-4 are downstream members of the extracellular signal-regulated kinase (ERK)/MAPK cascade. SL 0101-1 is a kaempferol glycoside, isolated from the tropical plant F. refracta, that selectively inhibits RSK2 with an IC50 value of 89 nM (Ki = 1 µM) without interfering with upstream activators of RSK, including ERK, MEK, EGFR, and PKC. At 100 µM, SL 0101-1 inhibits the proliferation of MCF-7 breast cancer cells, arresting cells in the G1 phase of the cell cycle. SL 0101-1 has been used to characterize the intracellular signaling events associated with angiotensin II-induced tyrosine kinase activation with a concentration of 30 µM attenuating angiotensin II-induced cell proliferation. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 3-[(3,4-di-O-acetyl-6-deoxy-a-L-mannopyranosyl)oxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one |
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| Gene, Accession, CAS # | CAS: 77307-50-7 |
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| Catalog # | LS-H9943 |
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| Order / More Info | SL 0101-1 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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