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| Product Name | SL 327 |
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| Description | Purity >95%. The dual specific threonine/tyrosine kinase MEK is a key component of the RAS/RAF/MEK/ERK signaling pathway that regulates a diverse array of cellular processes. SL 327 is an inhibitor of MEK1 and MEK2 (IC50 s = 0.18 and 0.22 µM), the kinases upstream of ERK1/2. It inhibits ERK1, MKK/p38, MKK4, JNK, and PKC at much higher concentrations (IC50 s = >50, 21, >100, >100, >10 µM, respectively). Since SL 327 rapidly passes the blood-brain barrier, it has been used to dissect the effect of RAS/RAF/MEK/ERK signaling pathway inhibition on behavior, including long-term memory, spatial learning, and fear/operant conditioning. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | a-[amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)-benzeneacetonitrile |
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| Gene, Accession, CAS # | CAS: 305350-87-2 |
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| Catalog # | LS-H9945 |
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| Order / More Info | SL 327 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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