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| Product Name | Y-27632 (hydrochloride) |
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| Description | Purity >98%. The ROCK family of Rho-associated serine-threonine protein kinases is known to play an important role in Rho-mediated cell adhesion and smooth muscle contraction. Y-27632 is a potent, ATP-competitive inhibitor of ROCKs including p160ROCK (Ki = 140 nM) and ROCK-II (IC50 = 800 nM). It also inhibits PRK2 with an IC50 value of 600 nM. One-hour treatment with 10 µM Y-27632 blocks apoptosis of dissociated cultured human embryonic stem cells, increasing cloning efficiency by 25% and sustaining survival up to 30 passages. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 4-[(1R)-1-aminoethyl]-N-4-pyridinyl-trans -cyclohexanecarboxamide, dihydrochloride |
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| Gene, Accession, CAS # | CAS: 129830-38-2 |
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| Catalog # | LS-H10536 |
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| Order / More Info | Y-27632 (hydrochloride) from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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