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| Product Name | Diphtheria Toxin, Strain NCTC10648 |
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| Description | Purity ~98% (SDS-PAGE). Diphtheria is a disease caused by Diphtheria toxin (DT), a potent exotoxin that is a member of the family of ADP-ribosylating bacterial toxins. DT is secreted by strains of the gram-positive bacterium Corynebacterium diphtheria carrying a lysogenic bacteriophage, which contains the toxin gene (Freeman, 1952). The toxin is secreted as a single polypeptide chain of 535aa (Mwt 58.342) containing two major functional domains, known as domains A and B. The amino terminal A domain (aa1-193) carries the catalytic domain for ADP-ribosylation of elongation factor 2 (EF2). The C-terminal B domain (aa194-535) is further divided into receptor (R) binding and transmembrane (T) domains (Choe, 1992). The B domain promotes binding of DT to cells, the internalization of DT by receptor-mediated endocytosis and the entry of the A polypeptide chain into the cytosolic compartment (Greenfield, 1983). In humans, DT binds to epidermal growth factor receptor (HB-EGFR) on the surface of cells, and the toxin-rec |
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| Size | 1mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 397635 |
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| Order / More Info | Diphtheria Toxin, Strain NCTC10648 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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