| 产品详情 |
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| Antigenic Specificity | DISP2 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse, rat |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 ug |
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| Concentration | n/a |
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| Applications | Western Blot: 1-2 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | DISP2 Polyclonal Antibody. Disp2 is the second of three known homologs of the D. melanogaster protein Dispatched. It is a multi-transmembrane protein containing two PTCH/DISP domains and is thought to be involved in the release of lipid-anchored Hedgehog from producing cells. Hedgehog is a major player in signaling pathways during embryogenesis, tissue regeneration, and carcinogenesis and the Disp proteins have been implicated in these pathways. Recently, it has been shown that Disp2 is translationally regulated by the microRNA miR-214 in zebrafish. Expression of this miRNA decreased Disp2 promoter activity in vitro and its overexpression in zebrafish resulted in a phenotype identical to that observed by Disp2 mutants. At least two isoforms |
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| Immunogen | n/a |
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| Other Names | DISPB, HsT16908; dispatched B; protein dispatched homolog 2 |
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| Gene, Accession # | Entrez: 214240, 311324, 85455; Uniprot: A7MBM2, Q8CIP5 |
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| Catalog # | PA5-20631 |
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| Price | |
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| Order / More Info | DISP2 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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