| 产品详情 |
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| Product Name | Recombinant Human Poliovirus receptor (PVR), partial |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 51.1kDa. Extracellular Domain: 21-343aa. N-terminal 6xHis-SUMO-tagged. Homo sapiens (Human). Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Nectin-like protein 5; NECL-5; CD_antigen: CD155 |
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| Gene, Accession, CAS # | PVR, UniProt: P15151 |
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| Catalog # | RPC21887 |
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| Order / More Info | Recombinant Human Poliovirus receptor (PVR), partial from BIOMATIK |
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| Product Specific References | n/a |
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