| 产品详情 |
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| Antigenic Specificity | LPIN1 |
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| Clone | OTI1B7 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1 |
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| Format | purified |
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| Size | 100 µl |
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| Concentration | n/a |
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| Applications | Immunohistochemistry (Paraffin): 1:150, Western Blot: 1:500 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | LPIN1 Monoclonal Antibody (OTI1B7). The Lipin family of nuclear proteins contains three members: Lipin-1, Lipin-2 and Lipin-3, all of which contain a nuclear signal sequence, a highly conserved amino-terminal (NLIP) domain and a carboxy-terminal (CLIP) domain. LPIN1 (Lipin-1) is crucial for normal adipose tissue development and metabolism. LPIN1 selectively activates a subset of PGC-1á target pathways, including fatty acid oxidation and mitochondrial oxidative phosphorylation by inducing expression of the nuclear receptor PPARá. LPIN1 also inactivates the lipogenic program and suppresses circulating lipid levels. An abundance of LPIN1 promotes fat accumulation and insulin sensitivity, whereas a deficiency in LPIN1 may deter normal |
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| Immunogen | n/a |
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| Other Names | LPIN1, PAP1, Lipin 1, fatty liver dystrophy protein, phosphatidate phosphatase LPIN1 |
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| Gene, Accession # | Entrez: 23175; Uniprot: Q14693 |
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| Catalog # | MA5-26770 |
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| Price | |
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| Order / More Info | LPIN1 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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