| 产品详情 |
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| Product Name | Suramin (sodium salt) |
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| Description | Purity >98%. Suramin is a polysulfonated naphthylurea that inhibits the binding of calmodulin to recognition sites on the ryanodine receptor-1 (IC50 = 4.9 µM), blocks G protein coupling to GPCRs, and non-selectively antagonizes P2 purinergic receptors (10-100 µM). Suramin also acts as a non-specific competitor of glycosaminoglycan binding to a variety of targets including TGFBeta, PDGF, and FGF and additionally inhibits insulin-like growth factor-l, EGF, PKC activity, TNF, IL-2, transferrin, and Apo-B. While originally used as an early stage treatment of trypanosome-caused onchocerciasis (African river blindness) and African trypanosomiasis (African sleeping sickness), suramin has been under clinical evaluation for its potential to regress a number of cancer cell lines, including non-small cell lung cancer, advanced breast cancer, hormone refractory prostate cancer, metastatic renal cell cancer, colorectal cancer, and high-grade gliomas. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 8,8'-[carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bis -1,3,5-naphthalenetrisulfonic acid, hexasodium salt, Germanin, BAY 205, NF 060 |
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| Gene, Accession, CAS # | CAS: 129-46-4 |
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| Catalog # | LS-H10076 |
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| Order / More Info | Suramin (sodium salt) from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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