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| Product Name | Kartogenin, CBF-beta Activator (2-(Biphenyl-4-ylcarbamoyl)benzoic Acid) |
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| Description | Purity ~99% (HPLC). A cell-permeable biphenylcarbamoylbenzoate compound that potently induces the differentiation of human mesenchymal stem cells (hMSCs) into chondrocytes (EC500nM). Reversibly binds to the FC-1 fragment of filamin A and disrupts its association with CBFB leading to nuclear localization of CBFB and binding to runt-related transcription factor (RUNX) to regulate chondrogenesis. Also reported to inhibit cytokine-induced release of nitric oxide (NO) and glycosaminoglycan (GAG). Exhibits chondroprotective properties and promotes cartilage repair in murine osteoarthritis models. Shown to up-regulate the levels of TIMP1, collagen, and aggrecan thereby blocking further matrix breaown without affecting the activities of MMP-3, MMP-13, and aggrecanase in primary chondrocytes or hMSCs. Formula: C20H15NO3 Molecular Weight: 317.3 Solubility: DMSO (100mg/ml) |
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| Size | 25mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217488 |
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| Order / More Info | Kartogenin, CBF-beta Activator (2-(Biphenyl-4-ylcarbamoyl)benzoic Acid) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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