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| Product Name | Apremilast |
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| Description | Purity >98%. Apremilast is an inhibitor of phosphodiesterase 4 (PDE4) with an IC50 value of 74 nM when tested in U937 cell lysates with 1 mM cAMP. It is orally active, significantly decreasing epidermal thickness and epithelial cell proliferation index in a mouse model of psoriasis. Apremilast reduces both TNF-Alpha and matrix metalloproteinase-3 production in gut lamina propria mononuclear cells from patients with inflammatory bowel disease. It also blocks spontaneous production of TNF-Alpha from human rheumatoid synovial cells and improves clinical score in mouse models of arthritis. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-[2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-acetamide, CC-10004 |
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| Gene, Accession, CAS # | CAS: 608141-41-9 |
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| Catalog # | LS-H6572 |
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| Order / More Info | Apremilast from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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