| 产品详情 |
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| Product Name | Aprepitant |
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| Description | Purity ≥98%. Aprepitant an antiemetic and antagonist of the neurokinin-1 (NK1) receptor (Ki = 3nM; IC50 = 0.09nM for the human receptor).It is selective for NK1 over NK3 receptors (Ki = 454.1nM for human NK3). In vivo, aprepitant (1mg/Kg) prevents plasma extravasation into the esophagus of guinea pigs induced by substance P. It also reduces NK1-agonist-induced foot tapping in gerbils. Formulations containing aprepitant have been used to prevent chemotherapy-induced nausea and vomiting. Synonyms: 5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one; Emend; L 754030; MK-869; ONO-7436 |
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| Size | 250mg, 500mg, 1g |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one; Emend; L 754030; MK-869; ONO-7436 |
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| Gene, Accession, CAS # | CAS: 170729-80-3 |
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| Catalog # | 259675 |
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| Order / More Info | Aprepitant from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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