| 产品详情 |
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| Antigenic Specificity | SDHD |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse, rat |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 ug |
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| Concentration | n/a |
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| Applications | Immunocytochemistry: 2.5 µg/mL, Immunofluorescence: 2.5 µg/mL, Western Blot: 1-2 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | SDHD Polyclonal Antibody. The mitochondrial succinate dehydrogenase complex subunit D (SDHD) is one of four proteins that make up the tricarboxylic cycle enzyme succinate dehydrogenase (SCH). Studies have shown that mutations in SDHD often leads to hereditary paragangliomas, usually benign tumors of the autonomic nervous system, suggesting that SDHD also plays a role as a tumor-suppressor gene. In one family with a nonsense mutation (R22X) in the SDHD gene, a loss of heterozygosity was found in the paragangliomas, and within these tumors the enzymatic activity of Complex II in the mitochondrial respiratory chain was completely abolished. Furthermore, high levels of angiogenic factors EPAS1 and VEGF was observed, which may stimulate tumor gr |
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| Immunogen | n/a |
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| Other Names | SDHD, Succinate dehydrogenase complex subunit D, succinate dehydrogenase cytochrome b small subunit mitochondrial, SDH4, PGL, PGL1, CBT1 |
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| Gene, Accession # | Entrez: 363061, 6392, 66925; Uniprot: O14521, Q6PCT8, Q9CXV1 |
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| Catalog # | PA5-34387 |
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| Price | |
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| Order / More Info | SDHD Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | PubMed: 25109264 |
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| 产品资料 |
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