| 产品详情 |
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| Antigenic Specificity | LSD1 |
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| Clone | E.289.8 |
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| Host Species | Mouse |
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| Reactive Species | human, mouse, nonhuman primate, rat |
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| Isotype | IgG1 |
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| Format | purified |
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| Size | 100 µL |
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| Concentration | n/a |
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| Applications | Western Blot: 1:1000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | LSD1 Monoclonal Antibody (E.289.8). LSD1 is a histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. LSD1 contains a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. It acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. LSD1 demethylates both mono- and tri-methylted 'Lys-4' of histone H3. This protein may play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3 'Lys-4' on nucleosomes and requires th |
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| Immunogen | n/a |
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| Other Names | BRAF35-HDAC complex protein BHC110; FAD-binding protein BRAF35-HDAC complex, 110 kDa subunit; amine oxidase (flavin containing) domain 2; flavin-containing amine oxidase domain-containing protein 2; lysine (K)-specific demethylase 1; lysine-specific histone demethylase 1; lysine-specific histone demethylase 1A |
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| Gene, Accession # | Entrez: 23028, 500569, 99982; Uniprot: O60341, Q6ZQ88 |
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| Catalog # | MA5-15026 |
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| Price | |
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| Order / More Info | LSD1 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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