| 产品详情 |
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| Antigenic Specificity | RAPGEF2 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | bovine, canine, equine, human, mouse, porcine, rabbit, rat |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 µl |
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| Concentration | n/a |
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| Applications | Immunohistochemistry: 1:100, Western Blot: 1.0 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | RAPGEF2 Polyclonal Antibody. Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Acts also as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP (PubMed:23800469, PubMed:10801446) or not (PubMed:10608844, PubMed:10548487, PubMed:11359771). Its binding to ligand-activated beta-1 adrenergic receptor ADRB1 leads to the Ras activation through the G(s)-alpha signaling p |
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| Immunogen | n/a |
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| Other Names | Rap guanine nucleotide exchange factor 2, Cyclic nucleotide ras GEF, CNrasGEF, Neural RAP guanine nucleotide exchange protein, nRap GEP, PDZ domain-containing guanine nucleotide exchange factor 1, PDZ-GEF1, RA-GEF-1, Ras/Rap1-associating GEF-1, RAPGEF2, KIAA0313, NRAPGEP, PDZGEF1 |
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| Gene, Accession # | Entrez: 100069003, 100139484, 100346752, 100517409, 100856359, 310533, 76089, 9693; Uniprot: F1M386, F1MSG6, F1PBJ0, Q8CHG7, Q9Y4G8 |
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| Catalog # | PA5-69195 |
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| Price | |
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| Order / More Info | RAPGEF2 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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