| 产品详情 |
| Edit |   |
|---|
| Antigenic Specificity | p130 |
|---|
| Clone | 130P215 (DCS-215) |
|---|
| Host Species | Mouse |
|---|
| Reactive Species | human, rat |
|---|
| Isotype | IgG1 |
|---|
| Format | purified |
|---|
| Size | 500 µL |
|---|
| Concentration | n/a |
|---|
| Applications | Immunofluorescence: Assay Dependent, Immunohistochemistry (Paraffin): 1:100, Immunoprecipitation: 2 µg/mL, Western Blot: 1-2 µg/mL |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | p130 Monoclonal Antibody (130P215 (DCS-215)). Two retinoblastoma-related proteins, p107 and pRb2/p130 are structurally and functionally similar to the product of the retinoblastoma gene (pRb/p105). Like pRb they bind transforming proteins of DNA tumor viruses through a particular region called the pocket domain. Both proteins play a fundamental role in growth control. The highest percentage of undetectable levels and the tightest inverse correlation with the histological grading and with PCNA expression in the most aggressive tumor types were found for pRb2/p130, which may suggest an important role for this protein in the pathogenesis and progression of lung cancer. |
|---|
| Immunogen | n/a |
|---|
| Other Names | 130 kDa retinoblastoma-associated protein, PRB2, RBR-2, retinoblastoma-like protein 2, retinoblastoma-related protein 2 |
|---|
| Gene, Accession # | Entrez: 5934, 81758; Uniprot: O55081, Q08999 |
|---|
| Catalog # | MA5-14305 |
|---|
| Price | |
|---|
| Order / More Info | p130 Antibody from INVITROGEN ANTIBODIES |
|---|
| Product Specific References | PubMed: 10766737, 21423621, 22179774 |
|---|
| 产品资料 |
|
|