| 产品详情 |
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| Antigenic Specificity | MST1-2/STK3-4 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 µL |
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| Concentration | n/a |
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| Applications | Immunohistochemistry: 1:50-1:200, Western Blot: 1:1,000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | MST1-2/STK3-4 Polyclonal Antibody. Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleu |
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| Immunogen | n/a |
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| Other Names | KRS2,STK4 |
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| Gene, Accession # | Entrez: 58231, 6789; Uniprot: Q13043, Q9JI11 |
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| Catalog # | A300-466A-M |
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| Price | |
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| Order / More Info | MST1-2/STK3-4 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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