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| Antigenic Specificity | MSL2 |
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| Clone | OTI4G7 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG2a |
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| Format | purified |
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| Size | 100 µl |
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| Concentration | n/a |
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| Applications | Western Blot: 1:500-1:2000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | MSL2 Monoclonal Antibody (OTI4G7). Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at lysine 16 which is implicated in the formation of higher-order chromatin structure. Acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub), but not that of H2A. This activity is greatly enhanced by heterodimerization with MSL1. H2B ubiquitination in turn stimulates histine H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1. |
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| Immunogen | n/a |
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| Other Names | KIAA1585; MSL2L1; RNF184 |
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| Gene, Accession # | Entrez: 55167; Uniprot: Q9HCI7 |
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| Catalog # | MA5-27413 |
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| Price | |
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| Order / More Info | MSL2 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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