| 产品详情 |
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| Antigenic Specificity | CHFR |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | bovine, canine, equine, guinea pig, human, mouse, rabbit, rat, zebrafish |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 µl |
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| Concentration | n/a |
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| Applications | Immunohistochemistry: 5 µg/mL, Western Blot: 0.2-1 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | CHFR Polyclonal Antibody. E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys-48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome. Promotes the ubiquitination and subsequent degradation of AURKA and PLK1. Probably acts as a tumor suppressor, possibly by mediating the polyubiquitination of HDAC1, leading to its degradation. May also promote the formation of ' |
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| Immunogen | n/a |
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| Other Names | Checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase, FLJ10796, FLJ33629, RNF116, RNF196 |
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| Gene, Accession # | Entrez: 100061394, 100355591, 100725607, 231600, 288734, 477434, 55743, 564271, 614816; Uniprot: A5WW08, Q810L3, Q96EP1 |
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| Catalog # | PA5-42327 |
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| Price | |
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| Order / More Info | CHFR Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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