| 产品详情 |
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| Antigenic Specificity | DC-SIGN |
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| Clone | 8B6 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1, kappa |
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| Format | purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Immunohistochemistry: 5-10 µg/mL, Western Blot: 1-2 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | DC-SIGN Monoclonal Antibody (8B6). Dendritic cells (DCs) that control immune responses were recently found to capture and transport HIV from the mucosal area to remote lymph nodes , where DCs hand over HIV to CD4+ T lymphocytes. DCs also amplify the amount of virus and extend the duration of viral infectivity. Multiple strains of HIV-1, HIV-2 and SIV bind to DCs via DC-SIGN. ICAM-3 is the natural ligand for DC-SIGN. A DC-SIGN homologue (termed DC-SIGNR, L-SIGN, and DC-SIGN2) was identified recently. DC-SIGN forms a novel gene family with DC-SIGNR and many alternatively spliced isoforms of DC-SIGN and DC-SIGNR are known to exisit (8). The expression of DC-SIGN was found in mucosal tissues including placenta, small intestine, and rectum. |
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| Immunogen | n/a |
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| Other Names | n/a |
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| Gene, Accession # | Entrez: 30835; Uniprot: Q9NNX6 |
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| Catalog # | MA5-15746 |
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| Price | |
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| Order / More Info | DC-SIGN Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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