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| Product Name | Human IL21 Protein (Recombinant) |
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| Description | Purity >95% by SDS-PAGE, MW: 15.4 kDa (SDS-PAGE). Interleukin-21 (IL-21) belongs to the Type I four helix bundle cytokines, and shares the common cytokine receptor gamma chain with IL-2, IL-4, IL-7, IL-9, and IL-15. IL-21 is expressed by CD4+ T cells, natural killer (NK) T cells, and Th17 cells, and the IL-21 receptor is highly expressed on CD4+ and CD8+ B cells; indeed, IL-21 plays a pivotal role in the survival and proliferation of B cells, and their differentiation to immunoglobulin (Ig) producing cells. IL-21 up-regulates and down-regulates the production of IgG1 and IgE by B cells, respectively, and diminishes the severity of allergy and asthma. In some case, IL-21 also induces the apoptosis of B cells. The other roles of IL-21 include regulation of innate immune systems, implication on autoimmunity, and antitumor actions.Recombinant human Interleukin-21 (rhIL-21) produced in E. coli is a single non-glycosylated polypeptide chain containing 132 amino acids. A fully biologically active molecule, rhIL-21 has a molecular mass of 15.4 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | IL21, Interleukin 21, Interleukin-21, Interleukin-21 isoform, Za11, IL-21 |
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| Gene, Accession, CAS # | IL21, Gene ID: 59067 |
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| Catalog # | LS-G27158 |
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| Order / More Info | Human IL21 Protein (Recombinant) from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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