| 产品详情 |
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| Antigenic Specificity | Securin |
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| Clone | 19H16L48 |
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| Host Species | Recombinant Rabbit |
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| Reactive Species | human, mouse |
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| Isotype | IgG |
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| Format | purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Immunocytochemistry: 2 µg/mL, Immunofluorescence: 2 µg/mL, Western Blot: 1-3 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Securin Antibody (19H16L48), ABfinity™ Rabbit Monoclonal. Pituitary tumor-transforming gene 1 (PTTG-1) is an oncogene expressed in normal tissues containing proliferating cells and in tumors. PTTG is downstream of the MAP kinase signaling cascade and is phosphorylated at Ser162 by MAPK in vitro. Phosphorylation plays an essential role in PTTG's transactivation function. The PTTG protein contains a DNA-binding domain, and it activates transcription of the c-Myc oncogene by binding to the promoter to form a complex. Studies have demonstrated that expression of human PTTG correlates with cell proliferation in a cell cycledependent manner, and the association of human PTTG with Ku, the regulatory subunit of DNA-dependent protein kinase, i |
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| Immunogen | n/a |
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| Other Names | EAP1, HPTTG, PTTG, TUTR1, ESP1-associated protein 1, pituitary tumor-transforming gene 1 protein, tumor-transforming protein 1 |
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| Gene, Accession # | Entrez: 30939, 9232; Uniprot: O95997, Q9CQJ7 |
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| Catalog # | 700791 |
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| Price | |
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| Order / More Info | Securin Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | PubMed: 25998394, 27509861, 28504713 |
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| 产品资料 |
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