| 产品详情 |
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| Antigenic Specificity | Securin |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | ELISA: Assay Dependent, Immunocytochemistry: 2 µg/mL, Immunofluorescence: 2 µg/mL, Immunohistochemistry: Assay Dependent, Western Blot: Assay Dependent |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Securin Polyclonal Antibody. Pituitary tumor-transforming gene 1 (PTTG-1) is an oncogene expressed in normal tissues containing proliferating cells and in tumors. PTTG is downstream of the MAP kinase signaling cascade and is phosphorylated at Ser162 by MAPK in vitro. Phosphorylation plays an essential role in PTTG's transactivation function. The PTTG protein contains a DNA-binding domain, and it activates transcription of the c-Myc oncogene by binding to the promoter to form a complex. Studies have demonstrated that expression of human PTTG correlates with cell proliferation in a cell cycledependent manner, and the association of human PTTG with Ku, the regulatory subunit of DNA-dependent protein kinase, is disrupted when a DNA double-stran |
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| Immunogen | n/a |
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| Other Names | EAP1, HPTTG, PTTG, TUTR1, ESP1-associated protein 1, pituitary tumor-transforming gene 1 protein, tumor-transforming protein 1 |
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| Gene, Accession # | Entrez: 9232; Uniprot: O95997 |
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| Catalog # | 34-1500 |
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| Price | |
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| Order / More Info | Securin Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | PubMed: 12960092, 15016801, 17039256, 18645228, 19211842, 20116377, 20436289, 21272169, 22200450, 22511756, 22789011, 23610398, 24637461, 25673878, 25723520, 25750436, 27196783, 27524416, 29387220 |
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