| 产品详情 |
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| Antigenic Specificity | Granzyme B |
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| Clone | GrB-7 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG2a |
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| Format | purified |
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| Size | 1 mL |
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| Concentration | n/a |
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| Applications | Immunohistochemistry (Paraffin): Assay dependent., Western Blot: 1:500 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Granzyme B Monoclonal Antibody (GrB-7). Granzyme B is a member of the granzyme serine protease family, and is found in the granules of cytotoxic T cells and NK cells. Granzyme B has been described as CGL1 (cathepsin G-like-1), a serine protease expressed only in cytotoxic T-lymphocytes after cell activation, and CTLA-1 (cytotoxic T lymphocyte-associated serine esterase 1) based on identification of mRNA in various cytotoxic T cells, but not observed in non-cytotoxic lymphoid cells. Granzyme B is crucial for the rapid induction of target cell death by apoptosis, induced by interaction with cytotoxic T cells. The receptor involved in this process has been identified as mannose 6-phosphate receptor which functions as a death receptor for Granz |
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| Immunogen | n/a |
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| Other Names | CCPI, CGL-1, CGL1, CSP-B, CSPB, CTLA1, CTSGL1, HLP, SECT |
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| Gene, Accession # | Entrez: 3002; Uniprot: P10144 |
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| Catalog # | MA1-35461 |
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| Price | |
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| Order / More Info | Granzyme B Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | PubMed: 19909745, 21245428, 7697916 |
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