| 产品详情 |
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| Antigenic Specificity | NADE |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 ug |
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| Concentration | n/a |
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| Applications | Immunohistochemistry: 2 µg/mL, Western Blot: 1 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | NADE Polyclonal Antibody. The p75 neurotrophin receptor (p75NTR) is a member of the tumor necrosis receptor superfamily and can mediate cell death and cell survival in response to nerve growth factor (NGF). The p75NTR-associated cell death executor (NADE) mediates apoptosis by interacting with the cell death domain of p75NTR following the binding of NGF by p75NTR. Recent studies have shown that NADE also interacts with second mitochondria-derived activator of caspase (Smac). Co-expression of NADE and Smac promotes TRAIL-induced apoptosis and inhibits XIAP-mediated Smac ubiquitization. It has been suggested that it is this interaction between NADE and Smac that allows apoptosis to proceed. Finally, although initially discovered as an mRNA ex |
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| Immunogen | n/a |
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| Other Names | RP13-349O20.1, BEX3, Bex, DXS6984E, HGR74, NADE; brain expressed, X-linked 3; brain-expressed X-linked protein 3; nerve growth factor receptor-associated protein 1; ovarian granulosa cell 13.0 kDa protein HGR74; ovarian granulosa cell protein (13kD); p75NTR-associated cell death executor; protein BEX3 |
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| Gene, Accession # | Entrez: 12070, 27018; Uniprot: Q00994, Q9WTZ9 |
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| Catalog # | PA5-20076 |
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| Price | |
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| Order / More Info | NADE Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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