| 产品详情 |
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| Product Name | Recombinant Human E3 ubiquitin-protein ligase pellino homolog 1 (PELI1) |
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| Description | Purity > 85% as determined by SDS-PAGE. MW: 50.4kDa. Full Length: 1-418aa. N-terminal 6xHis-tagged. Homo sapiens (Human). E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation. Mediates 'Lys-48'-linked polyubiquitination of RIPK3 leading to its subsequent proteasome-dependent degradation; preferentially recognizes and mediates the degradation of the 'Thr-182' phosphorylated form of RIPK3. Negatively regulates necroptosis by reducing RIPK3 expression. Mediates 'Lys-63'-linked ubiquitination of RIPK1. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Pellino-related intracellular-signaling molecule (RING-type E3 ubiquitin transferase pellino homolog 1) (Pellino-1) (PRISM) |
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| Gene, Accession, CAS # | PELI1, UniProt: Q96FA3 |
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| Catalog # | RPC26182 |
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| Price | |
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| Order / More Info | Recombinant Human E3 ubiquitin-protein ligase pellino homolog 1 (PELI1) from BIOMATIK |
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| Product Specific References | n/a |
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