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| Product Name | Recombinant Human 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 (PLCD4) |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 103.6kDa. Full Length: 1-762aa. N-terminal 6xHis-SUMO-tagged. Homo sapiens (Human). Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca2+ from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca2+ mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Phosphoinositide phospholipase C-delta-4Phospholipase C-delta-4; PLC-delta-4 |
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| Gene, Accession, CAS # | PLCD4, UniProt: Q9BRC7 |
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| Catalog # | RPC23579 |
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| Order / More Info | Recombinant Human 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 (PLCD4) from BIOMATIK |
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| Product Specific References | n/a |
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